Protein Interaction Networks—More Than Mere Modules
نویسندگان
چکیده
منابع مشابه
Protein Interaction Networks—More Than Mere Modules
It is widely believed that the modular organization of cellular function is reflected in a modular structure of molecular networks. A common view is that a "module" in a network is a cohesively linked group of nodes, densely connected internally and sparsely interacting with the rest of the network. Many algorithms try to identify functional modules in protein-interaction networks (PIN) by sear...
متن کاملMirin: identifying microRNA regulatory modules in protein-protein interaction networks
UNLABELLED Exploring microRNA (miRNA) regulations and protein-protein interactions could reveal the molecular mechanisms responsible for complex biological processes. Mirin is a web-based application suitable for identifying functional modules from protein-protein interaction networks regulated by aberrant miRNAs under user-defined biological conditions such as cancers. The analysis involves co...
متن کاملFinding functional modules in protein- protein interaction networks
Protein-protein interaction networks at the whole cell level have been established. The protein interaction networks data usually describe thousands of interactions among thousands of proteins and require specialized computer applications to analyze. What is more, single high throughput experiments are highly unreliable. Basic theoretical concepts for the description of biological networks will...
متن کاملDetecting functional modules in the yeast protein-protein interaction network
MOTIVATION Identification of functional modules in protein interaction networks is a first step in understanding the organization and dynamics of cell functions. To ensure that the identified modules are biologically meaningful, network-partitioning algorithms should take into account not only topological features but also functional relationships, and identified modules should be rigorously va...
متن کاملThe resolution of ambiguity during conversation: More than mere mimicry?
Interlocutors often omit important words during conversation, which can lead to miscommunication during ambiguous scenarios (Rayner, Carlson, & Frasyer, 1983). Haywood, Pickering and Branigan (2004) show that under ambiguous situations, listeners are highly sensitive to syntactic primes. The studies reported here evaluated the effects of linguistic and nonlinguistic cues to ambiguity. Experimen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2010
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1000659